The second woe:
And the sixth angel sounded, and I heard a voice from the four horns of the golden altar which is before God,  Saying to the sixth angel which had the trumpet, Loose the four angels which are bound in the great river Euphrates.
…and I heard a voice from the four horns of the golden altar which is before God. Three conclusions could be drawn from this passage:
1. The voice that John heard is the sprinkling blood of Christ that speaks as stated in the book of Hebrews.
And to Jesus the mediator of the new covenant, and to the blood of sprinkling, that speaketh better things than that of Abel.
The sprinkling of blood on the four horns of the golden altar is to take place in the day of atonement and to be performed by the high priest.
2. It’s the antitypical fulfillment of Exodus 30:10 and Leviticus 16:18-19 which states:
And he shall go out unto the altar that is before the Lord, and make an atonement for it; and shall take of the blood of the bullock, and of the blood of the goat, and put it upon the horns of the altar round about.  And he shall sprinkle of the blood upon it with his finger seven times, and cleanse it, and hallow it from the uncleanness of the children of Israel.
3. We read in Leviticus chapter 16 that the golden altar [altar of incense] was the last to be atone or cleanse, which will usher in the resurrection.
The last trump is to blown in the day of atonement.
Then shalt thou cause the trumpet of the jubile to sound on the tenth day of the seventh month, in the day of atonement shall ye make the trumpet sound throughout all your land.